Glenn C Telling Selected Research

Prions

1/2022	Tissue-specific biochemical differences between chronic wasting disease prions isolated from free-ranging white-tailed deer (Odocoileus virginianus).
1/2022	North American and Norwegian Chronic Wasting Disease Prions Exhibit Different Potential for Interspecies Transmission and Zoonotic Risk.
1/2021	Adaptive selection of a prion strain conformer corresponding to established North American CWD during propagation of novel emergent Norwegian strains in mice expressing elk or deer prion protein.
12/2020	Studies in bank voles reveal strain differences between chronic wasting disease prions from Norway and North America.
1/2020	Incomplete glycosylation during prion infection unmasks a prion protein epitope that facilitates prion detection and strain discrimination.
10/2019	Development of a new largely scalable in vitro prion propagation method for the production of infectious recombinant prions for high resolution structural studies.
1/2019	Primary structural differences at residue 226 of deer and elk PrP dictate selection of distinct CWD prion strains in gene-targeted mice.
1/2019	Application of PMCA to screen for prion infection in a human cell line used to produce biological therapeutics.
1/2019	Prion disease is accelerated in mice lacking stress-induced heat shock protein 70 (HSP70).
1/2018	Molecular Mechanisms of Chronic Wasting Disease Prion Propagation.

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Glenn C Telling Research Topics

Disease

36	Chronic Wasting Disease 01/2022 - 12/2004
23	Prion Diseases (Transmissible Spongiform Encephalopathies) 10/2019 - 01/2004
15	Infections 01/2020 - 10/2006
10	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 01/2008
7	Bovine Spongiform Encephalopathy (Mad Cow Disease) 01/2018 - 01/2004
6	Scrapie 01/2020 - 05/2004
5	Creutzfeldt-Jakob Syndrome (Creutzfeldt-Jakob Disease) 01/2019 - 05/2004
2	Brain Diseases (Brain Disorder) 01/2020 - 09/2008
2	Disease Progression 01/2019 - 12/2013
1	Spinal Cord Injuries (Spinal Cord Injury) 11/2020
1	Kuru 01/2018
1	Sporadic Creutzfeldt-Jakob Disease 01/2017
1	Proteostasis Deficiencies 10/2013
1	Traumatic Brain Injuries (Traumatic Brain Injury) 06/2013
1	Brain Injuries (Brain Injury) 06/2013
1	Disease Susceptibility (Diathesis) 10/2012
1	Body Weight (Weight, Body) 11/2011
1	Alzheimer Disease (Alzheimer's Disease) 04/2011
1	Asymptomatic Infections 11/2009
1	Amyloid Plaque 12/2004

Drug/Important Bio-Agent (IBA)

46	PrionsIBA 01/2022 - 05/2004
23	Prion ProteinsIBA 01/2020 - 01/2004
14	Proteins (Proteins, Gene)FDA Link 01/2021 - 08/2008
6	Peptide Hydrolases (Proteases)FDA Link 11/2020 - 05/2004
4	Protein Isoforms (Isoforms)IBA 01/2020 - 06/2010
2	calpastatinIBA 11/2020 - 06/2013
2	EpitopesIBA 01/2020 - 10/2012
2	Biological ProductsIBA 01/2019 - 10/2013
2	Complement System Proteins (Complement)IBA 12/2017 - 12/2013
2	Amyloid (Amyloid Fibrils)IBA 09/2015 - 04/2011
2	CalpainIBA 06/2013 - 05/2004
2	PrPSc ProteinsIBA 09/2011 - 06/2010
1	CalciumIBA 11/2020
1	Monoclonal AntibodiesIBA 01/2020
1	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 01/2019
1	VaccinesIBA 01/2018
1	Pharmaceutical PreparationsIBA 04/2014
1	Quinacrine (Mepacrine)IBA 04/2014
1	TEMPOIBA 02/2014
1	Glycoproteins (Glycoprotein)IBA 02/2014
1	Amino Acids FDA Link 10/2013
1	Alanine (L-Alanine)FDA Link 10/2013
1	Nucleic AcidsIBA 10/2013
1	collapsin response mediator protein-2IBA 06/2013
1	Voltage-Gated Sodium ChannelsIBA 06/2013
1	SpectrinIBA 06/2013
1	ClayIBA 01/2013
1	Bentonite (Montmorillonite)IBA 01/2013
1	Complement Receptors (Complement Receptor)IBA 11/2012
1	LipidsIBA 11/2012
1	Oxidants (Oxidizing Agents)IBA 11/2011
1	Peptides (Polypeptides)IBA 04/2011
1	AerosolsIBA 06/2010
1	4-O-carboxymethylascochlorinIBA 05/2010
1	AntibodiesIBA 09/2008
1	Codon (Codons)IBA 02/2008
1	Methionine (L-Methionine)FDA Link 02/2008
1	Leucine (L-Leucine)FDA Link 02/2008

Therapy/Procedure

1	Therapeutics 01/2019
1	Euthanasia (Mercy Killing) 06/2010
1	Blood Transfusion (Blood Transfusions) 05/2010